Protein S Activity, Plasma

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Protein S Activity, Plasma is a diagnostic test measuring the function of protein S, a critical clotting factor. It helps assess thrombotic risk.

Protein S Activity, Plasma

Overview

Protein S is a natural anticoagulant protein in blood plasma that regulates clotting. Protein S activity testing measures its functional effectiveness in preventing excessive blood clot formation, aiding in diagnosing conditions like thrombosis or assessing risk factors for clotting disorders. Results are typically reported as a percentage of normal activity, with lower levels indicating potential thrombotic risk. This test is crucial in managing conditions such as deep vein thrombosis, pulmonary embolism, and evaluating patients with suspected clotting disorders.


 

WHAT IS IT USED FOR?

Second-line testing for diagnosing inherited or acquired protein S deficiency serves as a supplement to initial testing using protein S antigen assay results (free protein S antigen, with or without total protein S antigen assay). This is particularly relevant when assessing patients with a history of venous thromboembolism.

 

METHOD NAME

Optical Clot-Based


AVAILABILITY

TBC

 

REPORTING NAME

Protein S Activity, P

 

ALIASES

  • Functional Protein S
  • Protein S Activity, Plasma
  • Protein S
  • ProteinS

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SPECIMEN TYPE

Plasma Na Cit

 

SHIPPING INSTRUCTIONS

TBC

 

SPECIMEN REQUIRED

Specimen Type: Platelet-poor plasma

Patient Preparation: The patient must not be receiving Coumadin.

Collection Container/Tube: Light-blue top (3.2% sodium citrate)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

  1. Centrifuge, transfer all plasma into a plastic vial, and centrifuge plasma again.
  2. Aliquot plasma into a plastic vial leaving 0.25 mL in the bottom of the centrifuged vial.
  3. Freeze the specimen immediately (no longer than 4 hours after collection) below -40 degrees C.

 

SPECIMEN MINIMUM VOLUME

0.5 mL

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