Primary Membranous Nephropathy Diagnostic Cascade, Serum

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Sequential testing identifies biomarkers and antibodies aiding in the diagnosis and management of membranous nephropathy.

Primary Membranous Nephropathy Diagnostic Cascade, Serum

Overview

The Primary Membranous Nephropathy Diagnostic Cascade involves a series of serological tests on serum to diagnose membranous nephropathy. It includes detecting autoantibodies like anti-PLA2R and anti-THSD7A, assessing kidney function, and identifying underlying causes. This diagnostic approach helps confirm the condition, differentiate it from other kidney diseases, guide treatment decisions, and monitor disease progression and response to therapy. It is crucial in managing patients with membranous nephropathy to optimize renal health and prevent complications like kidney failure.


 

WHAT IS IT USED FOR?

Differentiating between primary and secondary membranous nephropathy through an algorithmic method.

Observing patients with membranous nephropathy with minimal antibody levels.

Testing for anti-phospholipase A2 receptor antibodies.

 

METHOD NAME 

EURO: Enzyme-Linked Immunosorbent Assay (ELISA)

PLA2I, THSD7: Indirect Immunofluorescence Assay (IFA)

 

AVAILABILITY

TBC

 

REPORTING NAME

Prim Membranous Nephropathy Diag, S

ALIASES

  • Anti-PLA2R
  • PLA2R
  • Anti-THSD7A
  • Thrombospondin
  • THSD7

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SPECIMEN TYPE

Serum

 

SHIPPING INSTRUCTIONS

TBC

 

SPECIMEN REQUIRED

Supplies: Sarstedt Aliquot Tube, 5 mL

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.

 

SPECIMEN MINIMUM VOLUME 

1 mL

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